Searching for epistasis and linkage heterogeneity by correlations of pedigree‐specific linkage scores
نویسندگان
چکیده
منابع مشابه
A new strategy for linkage analysis under epistasis taking into account genetic heterogeneity.
BACKGROUND/AIMS Epistasis, the biological interaction of multiple genes modulating their individual effects, is likely omnipresent in complex diseases, and modelling epistasis in linkage studies can help detect loci with little marginal effect and detect epistatic effects themselves. We propose a complete three-step strategy for parametric linkage analysis under epistasis and heterogeneity in e...
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Many smoking-related phenotypes are substantially heritable. One genome scan of nicotine dependence (ND) has been published and several others are in progress and should be completed in the next 5 years. The goal of this hypothesis-generating study was two-fold. First, we present further analyses of our genome scan data for ND published by Straub et al. [1999: Mol Psychiatry 4:129-144] (PMID: 1...
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Logic regression has been recognized as a tool that can identify and model non-additive genetic interactions using Boolean logic groups. Logic regression, TASSEL-GLM and SAS-GLM were compared for analytical precision using a previously characterized model system to identify the best genetic model explaining epistatic interaction of vernalization-sensitivity in barley. A genetic model containing...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2008
ISSN: 0741-0395,1098-2272
DOI: 10.1002/gepi.20319